Bioinformatics and Functional Assessment of Toxin-Antitoxin Systems in Staphylococcus aureus
نویسندگان
چکیده
منابع مشابه
Toxin-Antitoxin Systems of Staphylococcus aureus.
Toxin-antitoxin (TA) systems are small genetic elements found in the majority of prokaryotes. They encode toxin proteins that interfere with vital cellular functions and are counteracted by antitoxins. Dependent on the chemical nature of the antitoxins (protein or RNA) and how they control the activity of the toxin, TA systems are currently divided into six different types. Genes comprising the...
متن کاملProteolytic regulation of toxin - antitoxin systems by ClpPC in Staphylococcus aureus 1 2
3 GlaxoSmithKline, King of Prussia, PA, 19406 8 9 *Corresponding author: 10 Department of Microbiology & Immunology, Dartmouth Medical School, Hanover, NH 11 03755 12 Phone: (603) 650-1310 Fax: (603) 650-1318 13 Email: [email protected] 14 15 16 17 Running Title: ClpPC degrades S. aureus antitoxins 18 Copyright © 2009, American Society for Microbiology and/or the Listed Authors/Insti...
متن کاملProteolytic regulation of toxin-antitoxin systems by ClpPC in Staphylococcus aureus.
Bacterial toxin-antitoxin (TA) systems typically consist of a small, labile antitoxin that inactivates a specific longer-lived toxin. In Escherichia coli, such antitoxins are proteolytically regulated by the ATP-dependent proteases Lon and ClpP. Under normal conditions, antitoxin synthesis is sufficient to replace this loss from proteolysis, and the bacterium remains protected from the toxin. H...
متن کاملRegulation of the mazEF toxin-antitoxin module in Staphylococcus aureus and its impact on sigB expression.
In Staphylococcus aureus, the sigB operon codes for the alternative sigma factor sigma(B) and its regulators that enable the bacteria to rapidly respond to environmental stresses via redirection of transcriptional priorities. However, a full model of sigma(B) regulation in S. aureus has not yet emerged. Earlier data has suggested that mazEF, a toxin-antitoxin (TA) module immediately upstream of...
متن کاملToxin-antitoxin (TA) systems are prevalent and transcribed in clinical isolates of Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus.
The percentage of bacterial infections refractory to standard antibiotic treatments is steadily increasing. Among the most problematic hospital and community-acquired pathogens are methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa (PA). One novel strategy proposed for treating infections of multidrug-resistant bacteria is the activation of latent toxins of toxin-anti...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Toxins
سال: 2018
ISSN: 2072-6651
DOI: 10.3390/toxins10110473